| 摘要 |
1477998 5 - Aroyl - 1- loweralkylpyrrole - 2- acetic acid derivatives McNEIL LABOBATORIES Inc 10 May 1976 [2 June 1975] 19072/76 Heading C2C 5 - Aroyl - 1 - lower alkylpyrrole - 2 - acetic acid derivatves of the Formula (I) in which R is C 1 -C 5 alkyl, R 1 is H or C 1 -C 5 alkyl, Z is CN or COO (C 1 -C 5 alkyl). and Ar is phenyl, thienyl, nitrophenyl, methylthiophenyl or trifluoromethylphenyl, or phenyl substituted by 1 to 3 C 1 -C 5 alkyl, C 1 -C 5 alkoxy or halogen atoms, are prepared by reacting a pyrrole derivative of the formula with an aroyl chloride of formula ArCOCl in an aprotic solvent in the absence of a catalyst. The compounds of Formula I may be hydrolysed to the acid of formula Reference has been directed by the Comptroller to Specifications 1,195,628 and 1,327,308. |
