AN IMPROVED METHOD OF PRODUCING INTRAVENOUSLY INJECTABLE GAMMA GLOBULIN

摘要

An improved process is provided for the preparation of a gamma globulin suitable for intravenous administration from the readily available Fraction II or II + III plasma protein paste or from the corresponding fractions originating from placental extracts. The Fraction II or II + III paste is extracted with water at a pH of 4.9 to 6.0 and impurities are fractionally precipitated by addition of polyethylene glycol to 4% of wt./vol. and then 6% vol. ethanol. The desired gamma globulin is then precipitated at a pH 8.0 by addition of polyethylene glycol to 12% wt./vol.