| 摘要 |
The compounds of the annexed formula <IMAGE> in which R stands for CH3S- or CH3O2S- and R1 stands for hydrogen or, if R denotes CH3O2S-, for an acyl radical of an aliphatic carboxylic acid having 15-17 C atoms or aminoacetic acid, are prepared by reaction of a compound of the annexed formula <IMAGE> with free trifluoroacetic acid or a functional derivative thereof. The corresponding esters, if R stands for CH3O2S-, are obtained by subsequent esterification to give the corresponding compound in which R1 is an acyl radical. The compound of the formula Ia in which R denotes CH3O2S and R1 denotes hydrogen is also prepared by oxidation of the corresponding methylmercapto compound using a peroxide compound. The esters of aminoacetic acid of the formula Ia can be converted into the corresponding therapeutically utilisable acid addition salts. The compounds obtained show a broad antibiotic spectrum of action and are highly suitable for use in human medicine. |
