Polymer factor IX moiety conjugates

摘要

Conjugates of a Factor IX moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is polyethylene glycol) or a derivative thereof. Also provided (among other things) are compositions comprising the conjugates, methods of making the conjugates, and methods of administering to a patient compositions comprising the conjugates.

主权项

1. A composition comprising a plurality of polyethylene glycol (PEG)-Factor IX moiety conjugates, the conjugates comprising a branched polyethylene glycol covalently attached via a spacer moiety comprised of one or more atoms to a Factor IX moiety that is either Factor IX or Factor IXa, where at least about 85% of the polyethylene glycol-Factor IX moiety conjugates in the composition are monoPEGylated.