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1. A compound selected from the group consisting of:
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(4-piperidyl)pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(4-piperidyl)pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aS,6aR)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrol[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aR,6aS)-2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aS,6aR)-2-ethyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aS,6aR)-2-(cyclopropylmethyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aS,6aR)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]-5-amino-pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aR,6aS)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]-6-methyl-pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-(2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl)-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]-2-amino-pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(2-ethyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aS,6aR)-2-isopropyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aS,6aR)-2-(2-phenylethyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aR,6aS)-2-(3-hydroxypropyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 3-hydroxypropyl (3aR,6aS)-2-[2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-(pyrazolo[1,5-a]pyrimidine-3-carbonylamino)pyrazol-1-yl]acetyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate, N-[1-[2-[(3aR,6aR)-2-methyl-3a-phenyl-3,4,6,6a-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, benzyl 4-[[(3aR,6aS)-5-[2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-(pyrazolo[1,5-a]pyrimidine-3-carbonylamino)pyrazol-1-yl]acetyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]methyl]piperidine-1-carboxylate, N-[1-[2-[(3aR,6aS)-2-[3-(2-oxopyrrolidin-1-yl)propyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aR,6aS)-2-(3-morpholinopropyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aR,7aS)-2,3,3a,4,5,6,7,7a-octahydropyrrolo[3,2-c]pyridin-1-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aS,7aR)-1,2,3,3a,4,6,7,7a-octahydropyrrolo[3,4-c]pyridin-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aS,6aR)-2-[(1-acetyl-4-piperidyl)methyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, ethyl 4-[[(3aS,6aR)-5-[2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-(pyrazolo[1,5-a]pyrimidine-3-carbonylamino)pyrazol-1-yl]acetyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]methyl]piperidine-1-carboxylate, N-[1-[2-[(3aS,7aR)-5-methyl-3,3a,4,6,7,7a-hexahydro-2H-pyrrolo[3,2-c]pyridin-1-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aR,7aS)-2-methyl-3,3a,4,6,7,7a-hexahydro-1H-pyrrolo[3,4-c]pyridin-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aR,6aS)-2-(tetrahydropyran-4-ylmethyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aS,6aR)-2-(3-methylsulfonylpropyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aS,6aR)-2-isobutyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(1-methyl-3,3a,4,6,7,7a-hexahydro-2H-pyrrolo[3,2-c]pyridin-5-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(5-methyl-3,3a,4,6,7,7a-hexahydro-1H-pyrrolo[3,4-c]pyridin-2-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aS,6aR)-2-(2-methylsulfonylethyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aS,6aR)-2-[3-(2-oxooxazolidin-3-yl)propyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aR,6aS)-2-[(4,4-difluorocyclohexyl)methyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aR,6aS)-2-[(1-methyl sulfonyl-4-piperidyl)methyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aR,6aS)-2-[[1-(tetrahydropyran-4-carbonyl)-4-piperidyl]methyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aR,6aS)-2-[[1-(dimethylcarbamoyl)-4-piperidyl]methyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aS,4S,6R,6aR)-6-(hydroxymethyl)-2-methyl-4-phenyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aR,6aS)-2-(3-methoxypropyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aR,6aS)-2-[(3-methyloxetan-3-yl)methyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aR,6aS)-2-(cyclobutylmethyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aR,7aS)-1-methyl-3,3a,4,6,7,7a-hexahydro-2H-pyrrolo[3,2-c]pyridin-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aS,7aR)-1-methyl-3,3a,4,6,7,7a-hexahydro-2H-pyrrolo[3,2-c]pyridin-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aS,6aS)-2-methyl-3a-phenyl-3,4,6,6a-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aR,6aR)-2-methyl-3a-phenyl-3,4,6,6a-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aS,7aR)-5-methyl-3,3a,4,6,7,7a-hexahydro-2H-pyrrolo[3,2-c]pyridin-1-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aS,6aR)-2-[(1-hydroxycyclohexyl)methyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aS,6aR)-2-[(1-cyanocyclohexyl)methyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aR,7aS)-5-methyl-3,3a,4,6,7,7a-hexahydro-2H-pyrrolo[3,2-c]pyridin-1-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aS,7aS)-5-methyl-3,3a,4,6,7,7a-hexahydro-1H-pyrrolo[3,4-c]pyridin-2-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aR,6aS)-2-(3-hydroxy-3-methyl-butyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 3-[(3aR,6aS)-5-[2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-(pyrazolo[1,5-a]pyrimidine-3-carbonylamino)pyrazol-1-yl]acetyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]propyl morpholine-4-carboxylate, N-[1-[2-[(3aR,6aS)-2-(cyclohexylmethyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aR,7aR)-5-methyl-3,3a,4,6,7,7a-hexahydro-1H-pyrrolo[3,4-c]pyridin-2-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aR,6aS)-2-[3-(2-oxoindolin-1-yl)propyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 3-[(3aS,6aR)-5-[2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-(pyrazolo[1,5-a]pyrimidine-3-carbonylamino)pyrazol-1-yl]acetyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]propyl cyclobutanecarboxylate, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(1-methyl-3,3a,4,6,7,7a-hexahydro-2H-pyrrolo[3,2-c]pyridin-5-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aS,6aR)-2-(cyclopropylmethyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]-2-amino-pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aS,6aR)-2-[(4,4-difluorocyclohexyl)methyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]-2-amino-pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aR,6aS)-2-(2,2,2-trifluoroethyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aR,6aS)-2-[2-[(4-chlorophenyl)methoxy]ethyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aR,7aR)-5-methyl-3,3a,4,6,7,7a-hexahydro-2H-pyrrolo[3,2-c]pyridin-1-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aS,7aS)-5-methyl-3,3a,4,6,7,7a-hexahydro-2H-pyrrolo[3,2-c]pyridin-1-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[2-cyanoethyl(methyl)amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[3-(dimethylamino)azetidin-1-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[3-(dimethylamino)pyrrolidin-1-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-(4-amino-1-piperidyl)-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(dimethylamino)-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1[2-[4-[2-methoxyethyl(methyl)amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-oxo-2-(4-pyrrolidin-1-yl-1-piperidyl)ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[(dimethylamino)methyl]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[(3R)-3-[(dimethylamino)methyl]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[(3S)-3-[(dimethylamino)methyl]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1[2-[4-[2-(dimethylamino)ethoxyl-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(dimethylamino)methyl]-4-hydroxy-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(ethylamino)-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[(3R)-3-hydroxypyrrolidin-1-yl]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[(3S)-3-hydroxypyrrolidin-1-yl]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[(2R)-2-[(dimethylamino)methyl]pyrrolidin-1-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[(2 S)-2-[(dimethylamino)methyl]pyrrolidin-1-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[(dimethylamino)methyl]-4-phenyl-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(2S)-2-(aminomethyl)pyrrolidin-1-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[(3S)-3-[(dimethylamino)methyl]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(methylamino)-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(cyclobutylamino)-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[methyl (2-phenylethyl)amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[methyl-[2-(2-pyridyl)ethyl]amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(2-cyanoethylamino)-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[[4-(dimethylamino)-4-oxo-butyl]-methyl-amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-oxo-2-[4-(2-phenylethylamino)-1-piperidyl]ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[2-(4-hydroxyphenyl)ethyl-methyl-amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[2-(4-hydroxyphenyl)ethylamino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[2-(4-chlorophenyl)ethylamino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-oxo-2-[4-[2-[4-(trifluoromethyl)phenyl]ethylamino]-1-piperidyl]ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[2-(4-chlorophenyl)ethyl-methyl-amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[2-(4-methoxyphenyl)ethyl-methyl-amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[methyl-[(3-methyloxetan-3-yl)methyl]amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[methyl-[2-[4-(trifluoromethyl)phenyl]ethyl]amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[4-[benzyl(methyl)amino]-1-piperidyl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[methyl(2,2,2-trifluoroethyl)amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[methyl(2-phenoxyethyl)amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[2-cyclohexylethyl(methyl)amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[(2,2-difluoro-2-phenyl-ethyl)-methyl-amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-oxo-2-[4-[2-phenylethyl(2,2,2-trifluoroethyl)amino]-1-piperidyl]ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[4-[2-(4-bromophenoxy)ethyl-methyl-amino]-1-piperidyl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[4-[2-(2-bromophenoxy)ethyl-methyl-amino]-1-piperidyl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[2-(2-chlorophenoxy)ethyl-methyl-amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[2-(4-chlorophenoxy)ethyl-methyl-amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[4-[butyl-[2-(4-methylphenoxy)ethyl]amino]-1-piperidyl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[4-[allyl-[2-(4-methylphenoxy)ethyl]amino]-1-piperidyl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[methyl-[2-(4-methylphenoxy)ethyl]amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[(4,4-difluoro-1-piperidyl)methyl]-4-phenyl-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[4-[1,3-benzodioxol-2-ylmethyl(methyl)amino]-1-piperidyl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[methyl-[(3-phenoxyphenyl)methyl]amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[(1-cyanocyclohexyl)methyl-methyl-amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[4-[butyl(2,2,2-trifluoroethyl)amino]-1-piperidyl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[4-[benzyl(2,2,2-trifluoroethyl)amino]-1-piperidyl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[(3-methyloxetan-3-yl)methyl-(3,3,3-trifluoropropyl)amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[4-[benzyl(3,3,3-trifluoropropyl)amino]-1-piperidyl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[4-[(4-bromophenyl)methyl-methyl-amino]-1-piperidyl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[4-[(4-tert-butylphenyl)methyl-methyl-amino]-1-piperidyl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[(3,4-dichlorophenyl)methyl-methyl-amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[4-[(3-bromophenyl)methyl-methyl-amino]-1-piperidyl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[methyl(3-phenylpropyl)amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[(4-isopropoxyphenyl)methyl-methyl-amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[(4-chlorophenyl)methyl-methyl-amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[4-[(4-butoxyphenyl)methyl-methyl-amino]-1-piperidyl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[methyl-[[3-(trifluoromethyl)phenyl]methyl]amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[(2,4-dimethylphenyl)methyl-methyl-amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[methyl (2-naphthylmethyl)amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[4-[(3-bromo-4-fluoro-phenyl)methyl-methyl-amino]-1-piperidyl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-oxo-2-[4-[(2,2,2-trifluoro-1-phenyl-ethyl)amino]-1-piperidyl]ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[4-[(1-benzyl-2,2,2-trifluoro-ethyl)-methyl-amino]-1-piperidyl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[2,2-difluoropropyl(methyl)amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(5-chloroisoindolin-2-yl)-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[3-(dimethylamino)pyrrolidin-1-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[2-(dimethylamino)ethoxyl-]-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[3-(dimethylamino)azetidin-1-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(dimethylamino)-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[2-hydroxyethyl(methyl)amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[2-methoxyethyl(methyl)amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[1-(3-acetamidopropyl)-4-piperidyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[1-[4-oxo-4-(1-piperidyl)butyl]-4-piperidyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[1-(1-acetyl-4-piperidyl)-4-piperidyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]-2-amino-pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[1-[1-(3-benzamidopropyl)-4-piperidyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[1-[3-(2-oxopyrrolidin-1-yl)propyl]-4-piperidyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[1-(4-morpholino-4-oxo-butyl)-4-piperidyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[1-[4-(dimethylamino)-4-oxo-butyl]-4-piperidyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[1-[4-(methylamino)-4-oxo-butyl]-4-piperidyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[1-(3-acetamidopropyl)-4-piperidyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]-2-amino-pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[1-[1-[3-[benzoyl(methyl)amino]propyl]-4-piperidyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[1-[4-oxo-4-(tetrahydropyran-4-ylamino)butyl]-4-piperidyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[1-[4-(oxetan-3-ylamino)-4-oxo-butyl]-4-piperidyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[1-[3-(3-methyl-2-oxo-imidazolidin-1-yl)propyl]-4-piperidyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[1-[3-(2-oxopyrrolidin-1-yl)propyl]-4-piperidyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[1-[4-(ethylamino)-4-oxo-butyl]-4-piperidyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[1-[2-(methylamino)-2-oxo-ethyl]-4-piperidyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[1-(3-morpholinopropyl)-4-piperidyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[1-(3-thiomorpholinopropyl)-4-piperidyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[1-[3-(methylamino)-3-oxo-propyl]-4-piperidyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[1-[3-(1,1-dioxo-1,4-thiazinan-4-yl)propyl]-4-piperidyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[1-[1-(4-amino-4-oxo-butyl)-4-piperidyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[1-[3-(2-oxoimidazolidin-1-yl)propyl]-4-piperidyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[1-[3-(3-methyl-2-oxo-imidazolidin-1-yl)propyl]-4-piperidyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[1-[1-(3-amino-3-oxo-propyl)-4-piperidyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[1-[1-[3-(3-benzyl-2-oxo-imidazolidin-1-yl)propyl]-4-piperidyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[1-[1-[4-(benzylamino)-4-oxo-butyl]-4-piperidyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[1-[4-(methylamino)-4-oxo-butyl]-4-piperidyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[1-(4-morpholino-4-oxo-butyl)-4-piperidyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[1-(4-amino-4-oxo-butyl)-4-piperidyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[1-(azepan-4-yl)-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(1-methyl azepan-4-yl)pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[1-[(1-acetyl-4-piperidyl)methyl]-4-piperidyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]-2-amino-pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(1-isobutyl-4-piperidyl)pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, ethyl 4-[4-[4-[(2-aminopyrazolo[1,5-a]pyrimidine-3-carbonyl)amino]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-1-yl]-1-piperidyl]butanoate, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[1-(3-hydroxypropyl)-4-piperidyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[1-(3-methylsulfonylpropyl)-4-piperidyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[1-(1-benzyl-4-piperidyl)-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[1-(4-phenylbutyl)-4-piperidyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[1-[1-(2-benzyloxyethyl)-4-piperidyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[1-[4-(2-phenylethoxy)butyl]-4-piperidyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[(3S)-1-methylpyrrolidin-3-yl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[(3R)-1-methylpyrrolidin-3-yl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(1-methyl-4-piperidyl)pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[(3R)-pyrrolidin-3-yl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[(3S)-pyrrolidin-3-yl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[4-[4-[(1-cyanocyclohexyl)methyl-methyl-amino]piperidine-1-carbonyl]phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4-(dimethylamino)-1-piperidyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4-[2-cyanoethyl(methyl)amino]-1-piperidyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4-[(dimethylamino)methyl]-1-piperidyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4-[2-(dimethylamino)ethyl]-1-piperidyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4-[methyl(2-phenylethyl)amino]-1-piperidyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[2-[4-[(4-amino-4-oxo-butyl)-methyl-amino]-1-piperidyl]-4-[5-chloro-2-(difluoromethoxy)phenyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4-(3-fluoroazetidin-1-yl)-1-piperidyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[3-(1-piperidyl)azetidin-1-yl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4-(3,3-difluoroazetidin-1-yl)-1-piperidyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4-[4-(dimethylamino)piperidine-1-carbonyl]-1-piperidyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4-[methyl(2,2,2-trifluoroethyl)amino]-1-piperidyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[2-[4-[butyl(methyl)amino]-1-piperidyl]-4-[5-chloro-2-(difluoromethoxy)phenyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4-[methyl-[(3-methyloxetan-3-yl)methyl]amino]-1-piperidyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[2-[4-[benzyl(methyl)amino]-1-piperidyl]-4-[5-chloro-2-(difluoromethoxy)phenyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4-[4-[methyl(2,2,2-trifluoroethyl)amino]piperidine-1-carbonyl]-1-piperidyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4-[(1-cyanocyclohexyl)methyl-methyl-amino]piperidyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4-[4-[(1-cyanocyclohexyl)methyl-methyl-amino]piperidine-1-carbonyl]-1-piperidyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-(4-methylpiperazin-1-yl)thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4-(2-phenylethyl)piperazin-1-yl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4-(cyclopropylmethyl)piperazin-1-yl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2[4-(2,2,2-trifluoroethyl)piperazin-1-yl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[3-(dimethylamino)prop-1-ynyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[2-[3-[butyl(methyl)amino]prop-1-ynyl]-4-[5-chloro-2-(difluoromethoxy)phenyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(7-methyl-2,7-diazaspiro[3.4]octan-2-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(7-methyl-2,7-diazaspiro[4.4]nonan-2-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(9-methyl-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(6-methyl-2,6-diazaspiro[3.3]heptan-2-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(9-methyl-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(2,7-diazaspiro[3.5]nonan-2-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(2-methyl-2,7-diazaspiro[3.5]nonan-7-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(2,6-diazaspiro[3.4]octan-6-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(2,7-diazaspiro[3.4]octan-2-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2(difluoromethoxy)phenyl]-1-[2-(2-methyl-2,6-diazaspiro[3.4]octan-6-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(8-methyl-2,8-diazaspiro[4.5]decan-2-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(2,8-diazaspiro[4.5]decan-8-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(2-methyl-2,8-diazaspiro[4.5]decan-8-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(2-isobutyl-2,8-diazaspiro[4.5]decan-8-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, benzyl 4-[[8-[2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-(pyrazolo[1,5-a]pyrimidine-3-carbonylamino)pyrazol-1-yl]acetyl]-2,8-diazaspiro[4.5]decan-2-yl]methyl]piperidine-1-carboxylate, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(4-methylpiperazin-1-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(2-hydroxyethyl)piperazin-1-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(2-methoxyethyl)piperazin-1-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(3-hydroxypropyl)piperazin-1-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[2-(2-hydroxyethoxy)ethyl]piperazin-1-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(2-methylsulfonylethyl)piperazin-1-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(4-ethylpiperazin-1-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[(3R)-3-(hydroxymethyl)-4-methyl-piperazin-1-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[(3S)-3-(hydroxymethyl)-4-methyl-piperazin-1-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(4-cyanophenyl)piperazin-1-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[(4-cyanophenyl)methyl]piperazin-1-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(4-methyl-1,4-diazepan-1-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(2-hydroxyethyl)-1,4-diazepan-1-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-(1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazin-2-yl)-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[(1S,5R)-8-methyl-3,8-diazabicyclo[3.2.1]octan-3-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(4-methylpiperazin-1-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(2-hydroxyethyl)piperazin-1-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(2-methoxyethyl)piperazin-1-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(4-methyl-1,4-diazepan-1-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2(4-ethylpiperazin-1-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(cyclopropylmethyl)piperazin-1-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-oxo-2-piperazin-1-yl-ethyl)pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1[2-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[(1R,4R)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4-[4-(dimethylamino)piperidine-1-carbonyl]phenyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-(4-pyridyl)thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4-[(dimethylamino)methyl]phenyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4-[(3-fluoroazetidin-1-yl)methyl]phenyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4-[(3,3-difluoroazetidin-1-yl)methyl]phenyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4-(4-methylpiperazin-1-yl)phenyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4-(4-methylpiperazine-1-carbonyl)phenyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[[4-(dimethylamino)-1-piperidyl]methyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[[methyl(2-phenylethyl)amino]methyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[2-[[(3aR,6aS)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]methyl]-4-[5-chloro-2-(difluoromethoxy)phenyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-(1-piperidylmethyl)thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[2-[(3aR,6aS)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carbonyl]-4-[5-chloro-2-(difluoromethoxy)phenyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4-(dimethylamino)piperidine-1-carbonyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(hydroxymethyl)-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[(2S)-2-(1,2-dihydroxyethyl)pyrrolidin-1-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(3-hydroxy-3-methyl-pyrrolidin-1-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[(3S)-3-hydroxypyrrolidin-1-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[(3R)-3-hydroxypyrrolidin-1-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-hydroxy-4-(hydroxymethyl)-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[2-(hydroxymethyl)morpholin-4-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(hydroxymethyl)-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(2-hydroxyethoxy)-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-hydroxy-4-(4-pyridyl)-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[2-(hydroxymethyl)morpholin-4-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(4-hydroxy-1-piperidyl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[1-[2-(4-benzyl-4-hydroxy-1-piperidyl)-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(4-hydroxy-4-methyl-1-piperidyl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(4-cyano-4-phenyl-1-piperidyl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(3,3-difluoropyrrolidin-1-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(4-cyano-4-phenyl-1-piperidyl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(3,6-dihydro-2H-pyridin-1-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-oxo-2-(4-phenoxy-1-piperidyl)ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(4-hydroxy-4-phenyl-1-piperidyl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(3,3-difluoropyrrolidin-1-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-morpholino-2-oxo-ethyl)pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(4-hydroxy-4-phenyl-1-piperidyl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-morpholino-2-oxo-ethyl)pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[[1-(hydroxymethyl)cyclopropyl]methylamino]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[(1-hydroxycyclopentyl)methyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[[1-(hydroxymethyl)cyclopropyl]-methyl-amino]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(2-methoxyethylamino)ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[1-(2-aminoethyl)-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[(1S,3R)-3-(methylamino)cyclohexyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[1-(3-aminocyclobutyl)-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[3-(methylamino)cyclobutyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[ethyl-[(2-methyl-4-pyridyl)methyl]amino]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[(2-chloro-4-pyridyl)methyl-ethyl-amino]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[ethyl(3-pyridylmethyl)amino]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[4-[4-(dimethylamino)piperidine-1-carbonyl]phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[4-[4-[methyl(2,2,2-trifluoroethyl)amino]piperidine-1-carbonyl]phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-(3-amino-3-imino-propyl)-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-(4-amino-4-imino-butyl)-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, ethyl 2-[2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-(pyrazolo[1,5-a]pyrimidine-3-carbonylamino)pyrazol-1-yl]ethylamino]acetate, cyclopentyl 2-[2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-(pyrazolo[1,5-a]pyrimidine-3-carbonylamino)pyrazol-1-yl]ethylamino]acetate, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-oxo-2-(1-piperidyl)ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, ethyl (2S)-2-amino-4-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-(pyrazolo[1,5-a]pyrimidine-3-carbonylamino)pyrazol-1-yl]butanoate, 2-[4-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperazin-1-yl]acetic acid, 2-[[1-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]ethyl)piperidin-4-yl]amino]acetic acid, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-[[2-(methylsulfanyl)ethyl]amino]ethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-(benzylamino)ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[(pyridin-2-ylmethyl)amino]ethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[(pyridin-4-ylmethyl)amino]ethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-oxo-2-[4-(1-phenylethyl)piperazin-1-yl]ethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(2-methylpropyl)piperazin-1-yl]-2-oxoethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-[4-[(3-methyloxetan-3-yl)methyl]piperazin-1-yl]-2-oxoethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-oxo-2-(4-propylpiperazin-1-yl)ethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-(4-benzylpiperazin-1-yl)-2-oxoethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2[4-[2-(morpholin-4-yl)ethyl]piperazin-1-yl]-2-oxoethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, methyl 2-[4-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperazin-1-yl]acetate, N-[3-[5-chloro-2-(difluoromethoxy)pyridin-3-yl]-1-[(5-oxooxolan-2-yl)methyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-oxo-2-(piperazin-1-yl)ethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-[4-[(dimethylcarbamoyl)methyl]piperazin-1-yl]-2-oxoethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-[[(2-hydroxyphenyl)methyl]amino]ethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-[[(3-hydroxyphenyl)methyl]amino]ethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-[[(4-hydroxyphenyl)methyl]amino]ethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, methyl 2-[[1-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperidin-4-yl]amino]acetate, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(5-hydroxy-2-oxopiperidin-1-yl)piperidin-1-yl]-2-oxoethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, methyl 3-[4-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperazin-1-yl]propanoate, 3-[4-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperazin-1-yl]propanoate, methyl 1-[2-[4-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperazin-1-yl]ethyl]piperidine-4-carboxylate, ethyl 1-[2-[4-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperazin-1-yl]ethyl]piperidine-4-carboxylate, methyl 1-[2-[4-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperazin-1-yl]ethyl]-4-methylpiperidine-4-carboxylate, 2-(morpholin-4-yl)ethyl 1-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperidine-4-carboxylate, ethyl 1-[2-[4-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperazin-1-yl]ethyl]-4-methylpiperidine-4-carboxylate, 2-(dimethylamino)ethyl 1-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperidine-4-carboxylate, 2-(morpholin-4-yl)ethyl 1-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)-4-methylpiperidine-4-carboxylate, 2-(dimethylamino)ethyl 1-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)-4-methylpiperidine-4-carboxylate, piperidin-4-ylmethyl 1-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperidine-4-carboxylate, 1-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperidine-4-carboxylic acid, 1-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)-4-methylpiperidine-4-carboxylic acid, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(4-[methyl[(5-oxooxolan-2-yl)methyl]amino]piperidin-1-yl)-2-oxoethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, methyl 3-[[1-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperidin-4-yl](methyl)amino]propanoate, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-([[4-(methylsulfanyl)phenyl]methyl]amino)ethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-oxo-2-[4-(2-oxooxan-4-yl)piperazin-1-yl]ethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(morpholin-4-ylmethyl)piperidin-1-yl]-2-oxoethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]-2-oxoethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-[4-[(4-methylpiperazin-1-yl)methyl]piperidin-1-yl]-2-oxoethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-oxo-2-[4-[(5-oxo-2,5-dihydrofuran-3-yl)methyl]piperazin-1-yl]ethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(4-[methyl[(5-oxo-2,5-dihydrofuran-3-yl)methyl]amino]piperidin-1-yl)-2-oxoethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 3-[4-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperazin-1-yl]propanoic acid, tert-butyl (3R,4R)-4-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]-3-hydroxypiperidine-1-carboxylate, (3S,4S)-4-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]-3-hydroxypiperidine-1-carboxylate, (3R,4R)-3-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]-4-hydroxypiperidine-1-carboxylate, tert-butyl (3S,4S)-3-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]-4-hydroxypiperidine-1-carboxylate, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[(3R,4R)-3-hydroxypiperidin-4-yl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[(3S,4S)-3-hydroxypiperidin-4-yl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[(3R,4R)-4-hydroxypiperidin-3-yl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[(3S,4S)-4-hydroxypiperidin-3-yl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, ethyl 2-[(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]ethyl)(pyridin-3-ylmethyl)amino]acetate, 2-[(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]ethyl)(pyridin-3-ylmethyl)amino]acetic, ethyl 2-[[1-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperidin-4-yl]amino]acetate, 2-[[1-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperidin-4-yl]amino]acetic acid, ethyl 2-(4-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]piperidin-1-yl)acetate, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[(1,3-oxazol-2-ylmethyl)amino]ethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[(pyridin-3-ylmethyl)amino]ethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[(2S)-2-(methylamino)propyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[(2S)-2-(dimethylamino)propyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[(2S)-2-(ethylamino)propyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-[4-[2-(methylsulfanyl)ethyl]piperazin-1-yl]-2-oxoethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-oxo-2-[4-(propan-2-yl)piperazin-1-yl]ethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(cyclopropylmethyl)piperazin-1-yl]-2-oxoethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(2,4-dimethylpiperazin-1-yl)-2-oxoethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(3,4-dimethylpiperazin-1-yl)-2-oxoethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-oxo-2-(2,2,4-trimethylpiperazin-1-yl)ethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-oxo-2-(3,3,4-trimethylpiperazin-1-yl)ethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-[4-[2-(dimethylamino)ethyl]piperazin-1-yl]-2-oxoethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(1,3-oxazol-2-ylmethyl)piperazin-1-yl]-2-oxoethyl]1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-[[(5-oxooxolan-2-yl)methyl]amino]ethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-oxo-2-[4-[(5-oxooxolan-2-yl)methyl]piperazin-1-yl]ethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-[4-[(methylcarbamoyl)methyl]piperazin-1-yl]-2-oxoethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-[[(1R)-1-phenylethyl]amino]ethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-[[(1S)-1-phenylethyl]amino]ethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, methyl 2-[(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]ethyl)amino]acetate, methyl (2S)-2-amino-4-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]butanoate, (1-methylpiperidin-4-yl)methyl 1-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperidine-4-carboxylate, (1-methylpiperidin-4-yl)methyl 1-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)-4-methylpiperidine-4-carboxylate, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-[methyl[(5-oxooxolan-2-yl)methyl]amino]ethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, ethyl 3-[[1-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperidin-4-yl](methyl)amino]propanoate, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1[2-oxo-2-[4-(5-oxooxolan-3-yl)piperazin-1-yl]ethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(morpholin-4-yl)piperidin-1-yl]-2-oxoethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[(2E)-4-(morpholin-4-yl)but-2-en-1-yl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[(2E)-4-(4-methylpiperazin-1-yl)but-2-en-1-yl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-(methylthio)ethyl 2-(2-(3-(5-chloro-2-(difluoromethoxy)phenyl)-4-(pyrazolo[1,5-a]pyrimidine-3-carboxamido)-1H-pyrazol-1-yl)ethylamino)acetate, ethyl 2-[4-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperazin-1-yl]acetate, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(4-methylpiperazine-1-carbonyl)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-((S)-tetrahydrofuran-3-ylamino)ethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-((2-(dimethylamino)-2-oxoethyl)(methyl)amino)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(2-(dimethylamino)-2-oxoethyl amino)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-((R)-tetrahydrofuran-3-ylamino)ethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-hydroxy-3-morpholinopropyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(3-(dimethylamino)-2-hydroxypropyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-hydroxy-3-(piperidin-1-yl)propyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(2-cyanoethyl)piperazin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-oxo-2-(4-(3-oxopiperazin-1-yl)piperidin-1-yl)ethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-oxo-2-(4-(piperazine-1-carbonyl)piperidin-1-yl)ethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(3-cyanopyrrolidin-1-yl)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-methyl-4-morpholinopiperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(3-(dimethylamino)-2-oxopropyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(3-morpholino-2-oxopropyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-((2-cyanopropyl)(methyl)amino)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(S)-3-cyano-1,4′-bipiperidin-1′-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(1-methylpiperidin-4-ylidene)ethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(4-methyl-3-oxopiperazin-1-yl)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(2-oxopiperazin-1-yl)ethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-oxo-3-(piperidin-1-yl)propyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(2-cyanopropylamino)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-((2-cyanoethyl)(methyl)amino)cyclohexylidene)ethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(2-cyanoethylamino)cyclohexylidene)ethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(1-(2-(4-aminocyclohexylidene)ethyl)-3-(5-chloro-2-(difluoromethoxy)phenyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(((S)-2-(dimethylcarbamoyl)pyrrolidin-1-yl)methyl)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-((S)-2-(dimethylcarbamoyl)pyrrolidin-1-yl)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(((S)-2-(methylcarbamoyl)pyrrolidin-1-yl)methyl)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-((S)-2-(methylcarbamoyl)pyrrolidin-1-yl)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-((4-(2-(dimethylamino)-2-oxoethyl)piperazin-1-yl)methyl)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-((1-(2-(dimethylamino)-2-oxoethyl)piperidin-4-yl)methyl)piperazin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-oxo-2-(4-(tetrahydro-2H-pyran-4-yl)piperazin-1-yl)ethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(1-methyl-hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-((1-cyanocyclopropyl)(methyl)amino)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(methyl((R)-tetrahydrofuran-3-yl)amino)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(1-(2-(4-(((1,3-dioxolan-2-yl)methyl)(methyl)amino)piperidin-1-yl)-2-oxoethyl)-3-(5-chloro-2-(difluoromethoxy)phenyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-oxo-2-(4-thiomorpholinopiperidin-1-yl)ethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(((1-(cyanomethyl)cyclopropyl)methyl)(methyl)amino)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(1-cyanocyclopropyl amino)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-oxo-2-(4-(tetrahydrofuran-3-yl)piperazin-1-yl)ethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(methyl((2-methyl-1,3-dioxolan-2-yl)methyl)amino)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(octahydropyrrolo[3,4-b]pyridin-6-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(1-methyl-octahydropyrrolo[3,4-b]pyridin-6-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(1-(2-(4-(1,4-oxazepan-4-yl)piperidin-1-yl)-2-oxoethyl)-3-(5-chloro-2-(difluoromethoxy)phenyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(methyl((S)-tetrahydrofuran-3-yl)amino)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-oxo-2-(4-thiomorpholinopiperidin-1-yl)ethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-((3aS,6aS)-hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-oxo-2-(4-(2-oxopiperazin-1-yl)piperidin-1-yl)ethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(3-cyanoazetidin-1-yl)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(1-(2-(4-((1S,4S)-5-oxa-2-aza-bicyclo[2.2.1]heptan-2-yl)piperidin-1-yl)-2-oxoethyl)-3-(5-chloro-2-(difluoromethoxy)phenyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(4-methyl-2-oxopiperazin-1-yl)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-((R)-3-methylmorpholino)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(1-(2-(4-(6-oxa-3-aza-bicyclo[3.1.1]heptan-3-yl)piperidin-1-yl)-2-oxoethyl)-3-(5-chloro-2-(difluoromethoxy)phenyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-((S)-3-methylmorpholino)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-((1-(piperidin-4-yl)-1H-1,2,3-triazol-4-yl)methyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(2-morpholino-2-oxoethoxy)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-((1-(1-methylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)methyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-((1-(1-(tetrahydrofuran-3-yl)piperidin-4-yl)-1H-1,2,3-triazol-4-yl)methyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(3-cyanopropylamino)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-((1-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-1,2,3-triazol-4-yl)methyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-oxo-2-(4-((tetrahydro-2H-pyran-4-yl)methyl)piperazin-1-yl)ethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(methyl(oxetan-3-yl)amino)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-oxo-2-(4-(2-thiomorpholinoethyl)piperazin-1-yl)ethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(3-cyanopropyl)piperazin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-cyano-1,4′-bipiperidin-1′-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(2,2-difluoropropylamino)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-((3-cyanopropyl)(methyl)amino)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-((2-cyano-2-methylpropyl)(methyl)amino)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(2-cyano-2-methylpropylamino)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(((1-cyanocyclopropyl)methyl)(methyl)amino)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, and N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(((1-cyanocyclopropyl)methyl)amino)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide,or a salt thereof. |
