| 摘要 |
1492897 Compositions containing antibiotic 342-14-I SHIONOGI & CO Ltd 10 June 1975 [19 June 1974] 24864/75 Heading A5B [Also in Division C3] A pharmaceutical composition comprises an antibiotic or an acid addition salt, metal salt or ammonium salt thereof, and a pharmaceutically acceptable diluent, carrier or excipient wherein said antibiotic, designated 342-14-I is a colourless amphoteric powder which melts with decomposition at 190- 195‹C, shows an elementary analysis of C 54.63%, H 7.12%, N 14.81%, O 23.44%, has a molecular weight of about 1450 and yields, upon acid hydrolysis, aspartic acid, threonine, glycine, valine, isoleucine, threonine, phenylalanine, tryptophan, 2, 4 - diaminobutyric acid, ammonia and anteisononanoic acid. The antibiotic is preferably obtained by cultivation of the microorganism Bacillus brevis. The composition may also comprise a stabiliser, an emulsifier, a preservative and/or a wetting agent, in the form of an injectable composition, a liquid, a suspension, a dispersion, an emulsion, an ointment, a tablet or a capsule. The compositions may be used to disinfect articles or building structures. For the inhibition of growth of grampositive pathogenic microorganisms in non- human animals it is preferred to use a dose of 0.1-100 mg of antibiotic per kg of body weieht via oral, subcutaneous or intravenous administration.
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