| 摘要 |
<p>1-Aryl-quinazol-4-one derivs. of formula (I) and their acid addn. salts are new. In the formula R1 is H or alkyl; R2 is H or CH3; R3 is CH3, CF3, NO2, Cl or F; and R4 is H, alkyl, OH, alkoxy, acyloxy, Cl, F, CF3 or NO2. Cpds. (I) are prepd. by reacting a 2-anilinobenzamide with ethyl orthoformate or R1COCl. (I) are variously useful as hypnotic-sedatives; tranquillisers; diuretics; antiinflammatories (antirheumatics) with low ulcerogenic tendency; and analgesics. The LD50 (intraperitoneally in mice) is >=200mg/kg for 15 of 16 cpds. quoted. A specified cpds. (I) is 1-(3-trifluoromethylphenyl)-1H-quinazolone-4.</p> |
