| 摘要 |
<p>New cpds. are 1,2-dithiole derivs. of formula (I): (where X1,X2 and X3 are H, 1-4 C alkyl or 1-4C alkoxy; at least one of X1,X2 and X3 being H; and Y is S, O or NOH). (I) have low toxicity and display marked chemotherapeutic properties. They are partic. useful as agents against bilharzia, and also have activity against amoebae. Specific cpds. (I) include 5-(2-pyrazinyl)-1,2-dithiole-3-thione. In an example, this cpd. is obtd. in a yield of 15.3g by refluxing 3-(2-pyrazinyl)-3-oxo-propionic acid ethyl ester (97g) with P2S5 (122g) in anhydrous pyridine (1220 ml).</p> |
