| 摘要 |
1491266 Aclacinomycins A and B ZAIDANHOJIN BISEIBUTSU KAGAKU KENKYUKAI 7 July 1975 [27 July 1974] 28465/75 Heading C2C [Also in Division C3] Novel aclacinomycins A and B having the general formula wherein R is a group of the formula and non-toxic acid addition salts thereof are prepared by culturing an aclacinomycin-producing strain of Streptomyces galilaeus having the identifying characteristics of ATCC 31133 under submerged aerobic conditions in a nutrient medium containing a carbon source and a nitrogenous nutrient until a substantial amount of aclacinomycin is produced by said organism in said nutrient medium, followed optionally by salification of the product. Pharmaceutical compositions having antitumour activity comprise, as active ingredient, at least one aclacinomycin as defined above, together with a pharmaceutically acceptable carrier or diluent.
|
