| 摘要 |
1491413 L - 3 - (3,4 - dihydroxyphenyl) - 2- methylalanine derivatives BOEHRINGER MANNHEIM GmbH 11 March 1976 [12 March 1975] 09735/76 Heading C2C [Also in Division C3] N - chloroacetyl - L - 3 - (3,4 - dihydroxyphenyl) - 2 - methylalaninemethylester is prepared by the reaction of chloroacetyl chloride and L - 3 - (3,4 - dihydroxyphenyl) - 2 - methylalaninemethylester, and hydrolysis with sodium hydroxide yields N - chloroacetyl - L- 3-(3,4-dihydroxyphenyl)-2-methylalanine. N - benzyloxycarbonyl - L - 3 - [3,4 - di - (benzyl oxycarbonyloxy)phenyl]- 2 - methylalanine is prepared by the reaction of L-3-(3,4-dihydroxyphenyl) - 2 - methylalanine with benzyl chloroformate, which is treated with IN aqueous sodium hydroxide to yield N-benzyloxycarbonyl- L-3-(3.4-dihydroxyphenyl)-2-methylalanine. |
