Process for the preparation of 17{62 -hydroxy-3-oxo-17{60 -pregn-4-ene-21-carboxylic acid {65 -lactone

摘要

A new process for the preparation of 17 beta -hydroxy-3-oxo-17 alpha -pregn-4-ene-21-carboxylic acid gamma -lactone is described herein. The process makes use of androst-4-ene-3,17-dione as the starting material and 17 alpha -ethynyl-17 beta -hydroxyandrost-4-en-3-one as an early intermediate.