发明名称 |
ANALOGS OF DEAMINO-VASOPRESSIN WITH A MODIFIED DISULFIDE BRIDGE AND MANUFACTURING PROCESS THEREOF |
摘要 |
<p>Stepwise synthesis in solution and cyclization by means of active esters or another method suitable for peptide bond formation were used to prepare analogues of deamino-vasopressin with the disulphide bridge altered to the thioether group. In sequence position 8 of the peptide chain the analogs differed by the nature of basic amino acid. Typical vasopressin-like activities, mainly antidiuretic, were very high in these analogs; of particular importance will be their haemodynamic activity.</p> |
申请公布号 |
CA1020547(A) |
申请公布日期 |
1977.11.08 |
申请号 |
CA19740213092 |
申请日期 |
1974.11.04 |
申请人 |
CESKOSLOVENSKA AKADEMIE VED |
发明人 |
PROCHAZKA, ZDENKO;BARTH, TOMISLAV;CORT, JOSEPH H.;SORM, FRANTISEK;JOST, KAREL |
分类号 |
A61K38/00;A61K38/11;A61P5/00;C07K1/113;C07K5/103;C07K7/16;C07K14/575 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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