| 摘要 |
1490660 2-Aminoethyl substituted dibenzocycloheptene SANDOZ Ltd 18 April 1975 [22 April 1974] 16001/75 Heading C2C Novel compounds of the Formula I wherein R 1 and R 2 , independently are hydrogen, or fluorine, and either R 3 and R 4 independently are C 1-2 alkyl or R 3 is hydrogen and R 4 is methyl and acid addition salts thereof may be prepared by hydrogenating a compound of the Formula II 10 - (2 - Dimethylaminoethyl)- 10,11 - dihydro - 5 - methylene - 5H - dibenzo[a,d]cycloheptene is prepared by dehydration of 10-(2- dimethylaminoethyl) - 10,11 - dihydro - 5- methyl-5H-dibenzo[a,d]cyclohepten-5-ol. 10 - (2 - Methylaminoethyl) - 10,11 - dihydro- 5 - methylene - 5H - dibenzo[a,d]cycloheptene is prepared by treating the dimethylaminoethyl product above with ethyl chloroformate and decarboxylating the intermediate carbamic acid ester. Pharmaceutical compositions of compounds I with the usual excipients show anti-depressive activity when administered parenterally.
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