| 摘要 |
D 4-3-Keto-6a -methyl-steroid compounds of the androstane, 19-nor-androstane, pregnane and 19-nor-pregnane series having a saturated ring B are prepared by catalytically hydrogenating D 4-3-keto-6-dichloromethylene and D 4-3-keto-6-dibromoethylene compounds of the said series and treating the hydrogenation product with a strong inorganic acid. Suitable hydrogenation catalysts are noble metal catalysts, Raney nickel and palladium on a carrier such as an alkaline earth metal carbonate. The reaction is preferably carried out in the presence of an acid binding agent such as an aliphatic tertiary amine. In the examples 6a -methyl-testosterone, 6a -methyl-progesterone, 6a -methyl-19-nor-testosterone acetate, 6a ,17a -dimethyl-testosterone, 6a -methyl-17a -acetoxyprogesterone and the corresponding 17a -caproate, phenylacetate, propionate and b -cyclopentylpropionate, 6a -methyl-17a -hydroxy-11-desoxycorticosterone 21-acetate, and 6a -methyl-cortisone acetate are prepared. Specification 862,235 is referred to. Reference has been directed by the Comptroller to Specification 802,005. |
