ALKALI METAL AND ALKALINE EARTH METAL SALTS OF HEXAHYDROPYRIMIDINE-1,3-DIACETATE AND 5-HYDROXYHEXAHYDROPYRIMIDINE-1,6-DIACETATE

摘要

N,N'-Dicarboxymethyl-1,3-propanediamine (designated PDDA) is prepared by reacting 1,3-propanediamine with formaldehyde and HCN to form hexahydropyrimidine-1,3-diacetonitrile, which is hydrolyzed with an aqueous alkali metal hydroxide to form dialkali metal hexahydropyrimidine-1,3-diacetate which, in turn, is reacted with mineral acid to form the desired PDDA and formaldehyde.