| 摘要 |
Disclosed herein is an improved process for the production of carboxamides of 3,4-dihydro-oxo-1,2-benzothiazine-1,1-dioxides. Said process comprises contacting either a 3-oxo- or 4-oxo-1,2-benzothiazine-1,1-dioxide with a known or readily prepared phenylisocyanate to produce the corresponding 4- or 3-carboxanilide followed by a transamidation with an amine whose own isocyanate is frequently unstable to produce carboxamide with previously disclosed pharmaceutical value as a non-steroidal anti-inflammatory agent. |
