| 摘要 |
1,3-Benzodioxol derivatives, the new compounds, represented by the formula: <IMAGE> AND THE PHARMACOLOGICALLY ACCEPTABLE ACID-ADDITION SALTS THEREOF ARE PROVIDED, WHEREIN R1 and R2 are lower alkyls or the both together may form a divalent alkylene, R3 is a lower alkyl, phenyl, halogen-substituted phenyl or benzhydryl group, n is an integer of 2 or 3, and X stands for carbonyl (CO) or methylene (CH2) bridge. The compounds in which X stands for the methylene exhibit durable anti-histamic activity with low toxicity, and are useful for therapeutic purposes, while the compounds in which X stands for the carbonyl bridge are easily convertible by reduction into the former compounds.
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