摘要 |
Novel steroid ethers are disclosed, which are represented by the formula: <IMAGE> wherein Z is selected from the group consisting of >C=O >CHOH, and <IMAGE> X is selected from the group consisting of -H and -OH, and R is selected from the group consisting of <IMAGE> and <IMAGE> wherein R1 is a straight or branched chain hydrocarbon of from 1 to about 16 carbon atoms; A is selected from the group consisting of -CH2-, >C=O, and >CHOR3; Y may be a single bond or a double bond; R2 and -R1O- represent substituents on the aromatic ring of the group of the second formula, in either the 2 or 4 positions, and R2 is selected from the group consisting of H and OR3; R3 is selected from the group consisting of lower alkyl of from 1 to about 6 carbon atoms; lower acyl of from 1 to about 6 carbon atoms; monocyclic aryl of about 6 to 8 carbon atoms; and monocyclic aralkyl, that is, an alkyl group having an aryl substituent thereon, wherein the alkyl group has 1 to about 5 carbon atoms and the aryl group has about 6 to 8 carbon atoms. Also disclosed are methods for making the above compounds.
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