FORFARANDE FOR FRAMSTELLNING AV 7-ALKOXI- ELLER 7-ARALKOXI-3-KLORMETYLCEFEMER

摘要

7-Alkoxy-3-chloromethyl-3-cephems are provided by reacting a 3-methylenecepham with an alkali metal salt of a lower primary alcohol in the presence of tert-butyl hypochlorite at a temperature ranging from about -80 DEG to about 0 DEG C. The 3-chloromethylcephems provided by this invention are useful intermediates for the preparation of known cephalosporin antibiotics.