Preparation of N-(aminoalkyl)piperazine

摘要

An improved process for selectively preparing an N-(aminoalkyl)piperazine compound is disclosed wherein piperazine is contacted with a primary or secondary amino alkanol compound in the presence of a catalytically effective amount of a phosphorus-containing substance at a temperature of from about 250 DEG to about 350 DEG C under a pressure sufficient to maintain the mixture essentially in liquid phase and the N-(aminoalkyl)piperazine is then recovered from the resultant reaction mixture. In a preferred embodiment piperazine is contacted with monoethanolamine to produce N-(2-aminoethyl)-piperazine.