| 摘要 |
<p>1449388 Hydrocinnamic acid nitriles F HOFFMAN-LA ROCHE & CO AG 8 Nov 1974 [8 Nov 1973 (2)] 05397/76 Divided out of 1449387 Heading C2C Novel compounds of Formula I wherein R<SP>1</SP> and R<SP>2</SP> are C 1-3 alkyl, R<SP>3</SP> is halogen and R<SP>5</SP> is an ether group a thioether group or an amino group derived from a primary or secondary amine are prepared by reaction of an appropriate benzaldehyde with a suitable propionitrile or by reaction of anα-(methylsulphonylmethyl)-benzyl alcohol with a suitable propionitrile. 4 - Chloro 3, - 5 - dimethoxy -α- (methylsulphonylmethyl) - benzyl alcohol is prepared by reduction od 41 - chloro - 3<SP>1</SP>,5<SP>1</SP> - dimethoxy- 2-methyl sulphonyl acetophenone which is obtained by reaction of dimethylsulphone and ethyl 4 - chloro - 3,5 - dimethyoxybenzoate obtained by esterification of the acid. The benzaldehydes intermediates and obtained either from the corresponding acid chlorides orα- (methylsulphonylmethyl) benzyl alcohols. Intermediates prepared in preparation of above starting materials are the acid chlorides 3 - hydroxy - 5 - keto - 4 - phenylazo - 3 - cyclohexene carboxylic acid and its methyl ester, 3,5- dihydroxy - 4 - phenylazobenzoic acid, 3,5 - dimethoxy - 4 - phenylazobenzoic acid methyl ester, 4 - amino - 3,5 - dimethoxybenzoic acid methyl ester, 4<SP>1</SP> - amino - 3<SP>1</SP>,5<SP>1</SP> - dimethoxy- 2 - methylsulphonylacetophenone and 3,5- dimethoxy-4-iodobenzaldehyde.</p> |
