发明名称 |
LOWERALKYL IMIDAZOLE CARBOXYLATES |
摘要 |
Optically active C1-C3-alkyl esters of 1-(1-phenylethyl)-1H-imidazole-5-carboxylic acid are prepared by reacting racemic 1-(1-phenylethyl)-1H-imidazole-5-carboxylic acid with an optically active isomer of 1-phenylethylamine, 1-(1-naphthyl)ethylamine or 1-(2-naphthyl)ethylamine. The resulting insoluble diastereomeric salt is separated off and treated with a strong non-oxidising mineral acid. The resulting optically active 1-(1-phenylethyl)-1H-imidazole-5-carboxylic acid is then esterified with a C1-C3-alcohol. In another process, the resulting optically active acid is firstly converted into the acid halide and then correspondingly esterified. The prepared compounds can be used as hypnotics. |
申请公布号 |
AU1180676(A) |
申请公布日期 |
1977.09.15 |
申请号 |
AU19760011806 |
申请日期 |
1976.03.09 |
申请人 |
JANSSEN PHARMACEUTICA N.V. |
发明人 |
LEOPOLD FR. C. ROEVENS;JOSEF J. P. HEYKANTS;WALTER A. M. HELSEN |
分类号 |
C07D233/66;A61K31/4164;C07D233/90 |
主分类号 |
C07D233/66 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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