{60 -AMINOMETHYL-4-HYDROXY-3-METHYLSULFONYL BENZYL ALCOHOLS

摘要

alpha -Aminomethyl-4-hydroxy-3-methylsulfonyl benzyl alcohols having beta -adrenergic antagonist activity are prepared generally from 4-benzyloxy-3-methylsulfonylacetophenone by, for example, bromination and treatment of the resulting alpha -bromo derivative with an N-benzyl secondary amine, followed by catalytic hydrogenation to remove protective benzyl groups and reduce the ketone moiety.