发明名称 |
Trioxopteridine derivatives suitable as medicament |
摘要 |
Trioxopteridine derivatives of the formula <IMAGE> , wherein R1 is a normal alkyl group having 0 to 6 hydroxyl groups and R2 is hydrogen or a normal lower alkyl group having 0 to 5 hydroxyl groups, are prepared by catalytically hydrogenating a 6-substituted-5-nitro-2,4-dioxopyrimidine to give a 6-substituted-5-amino-2,4-dioxopyrimidine, and then reacting the latter compound with a compound of the formula R2-A-COOR3, wherein R3 is hydrogen, lower alkyl, an alkali metal or an alkaline earth metal and A is carbonyl or a group of the formula <IMAGE> wherein R4 is lower alkyl. The resulting trioxopteridine derivatives have analgesic and antiphlogistic properties and are therefore useful as pharmaceutical medicaments.
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申请公布号 |
US4046893(A) |
申请公布日期 |
1977.09.06 |
申请号 |
US19760650749 |
申请日期 |
1976.01.20 |
申请人 |
NIPPON ZOKI PHARMACEUTICAL CO., LTD. |
发明人 |
TAKINO, MASUICHI;KUROSAKI, TEIKICHI;ODAKA, MUNEHIKO |
分类号 |
A61K31/505;(IPC1-7):A61K31/50 |
主分类号 |
A61K31/505 |
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地址 |
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