| 摘要 |
1426199 Penicillins BAYER AG 30 Nov 1973 [1 Dec 1972 4 April 1973] 55668/73 Addition to 1301962 Heading C2C The invention comprises the compounds of formula and their salts, wherein (i) R is Me and B is either 1,4-cyclohexadien-1-yl or p-hydroxyphenyl, or (ii) R is H and B is 1,4-cyclohexadien-1-yl. In examples, these compounds are prepared by reacting the corresponding NH 2 -terminated penicillin with 2-oxo-imidazolidin-1-carbonyl chloride or its N-methyl derivative, and are converted to the Na salts. Pharmaceutical and veterinary compositions having antibacterial and growth promoting activity comprise compounds of the above formula, and may be administered orally, parenterally, rectally or locally. |
