Broad-spectrum cephalosporin antibiotics resistant to beta-lactamase - 7-(alpha-(4pethyl-2,3-dioxo-piperazinocarbonylamino)-para-hydroxy- phenylacetamido)-ceph-3-em-4-carboxylic acids

摘要

Cephalosporins of formula (I): (where R1 = H, a cation or a blocking group and R2 = acetoxy (cpd. C) carbamyloxy (cpd. D), 5-methyl-1,3,4-thiazol-2-ylthio (cpd. B) or 1-methyl-1,2,3,4-tetrazol-5-ylthio (cpd. A)), are broad spectrum antibiotics effective against Gram-positive and Gram-negative bacteria (partic. Pseudomonas aeruginosa, Klebsiella pneumoniae and Proteus species) and stable to bacterial beta-lactamase. The cpds. have low toxicity, are well absorbed to give high blood levels and do not show hemolytic activity.