发明名称 |
Acylimine cephalosporins |
摘要 |
A process is provided which yields derivatives of cephalosporins and penicillins. The process starts with 7-acylaminocephalosporin, or 6-acylaminopenicillin, then the latter compounds are treated with an organolithium compound, followed with t-butyl-hypochlorite. Finally, a defined reagent is added yielding a side chain on the carbon adjacent to the amino-nitrogen. Novel intermediate compounds are also described. The end compounds prepared are active against both gram-positive and gram-negative bacteria.
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申请公布号 |
US4041029(A) |
申请公布日期 |
1977.08.09 |
申请号 |
US19750615856 |
申请日期 |
1975.09.23 |
申请人 |
MERCK & CO., INC. |
发明人 |
FIRESTONE, RAYMOND A.;CAMA, LOVJI D.;CHRISTENSEN, BURTON G. |
分类号 |
A61K31/545;A61K31/546;A61P31/04;C07D499/00;C07D499/04;C07D499/10;C07D499/21;C07D499/44;C07D499/46;C07D499/68;C07D499/70;C07D499/72;C07D501/04;C07D501/16;C07D501/57;(IPC1-7):C07D501/16;C07D499/02 |
主分类号 |
A61K31/545 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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