PROCESS FOR PREPARING 2,5-DISUBSTITUTED BENZAMIDE

摘要

1420540 Process for 2,5-disubstituted benzamides SOC D'ETUDES SCIENTIFIQUES ET INDUSTRIELLES DE L'ILE DE-FRANCE 26 Feb 1974 [28 Feb 1973] 8664/74 Heading C2C Compounds of Formula (I) are made by reacting a 2,5-disubstituted benzoic acid with carbonyl di-imidazole to give compounds of Formula (IV) (not isolated) and thereafter reacting (IV) with H 2 N(CH 2 ) n A (I may, if desired, be converted into salts; A is mono- or di-C 1-5 alkylamino, or a heterocyclic saturated ring containing N and optionally O and/or S, B is C 1-5 alkyl or alkenyl, n is 1 or 2and X is NH 2 , mono- or di-alkylamino, alkenyl or alkyl). A is, e.g. diethylamino.