| 摘要 |
The present invention relates to the new antibiotic polymyxine methyl tetracycline wide spectrum salts of the general formula [(TH<+>-CO-NH-CH2-NH)n-P, nA<=>], m HB<-> in which m and n represent positive integers of less than 6, A<=> and B<-> represent mineral or organic anions, T represents an antibiotic residue of the tetracycline family of the formula T-CO-NH2, P represents a polypeptidic antibiotic residue of the polymyxine family of the formula P-(NH2)n, and particularly tri(oxytetracycline methyl) colistine trichloride-sulfate. The present invention also relates to the methods of preparing antibiotic salts by preparing the methylols of tetracycline salts by the addition of formol to the tetracycline salts, then, with or without isolation of this intermediate product, condensing it with an antibiotic of the polymyxine family. The present invention also relates to medications and pharmaceutical forms containing the products of the invention.
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