| 摘要 |
<p>1475913 Phenylpropanolamines BOEHRINGER INGELHEIM GmbH 9 Oct 1974 [11 Oct 1973] 43792/74 Heading C2C Compounds of the general formula (R 1 = H, halogen, CF 3 , OH, C 1-4 alkyl or alkoxy; R 2 = H, C 1-4 alkyl, benzyl) and their salts are prepared by (a) reducing a compound of the formula (R 2 <SP>1</SP> = R 2 , C 1-4 alkanoyl, benzoyl; R 3 =alkoxy, substituted alkoxy) with a complex hydride and, if necessary, deacylating the product, (b) removing the protecting group(s) in a compound of the formula (R 4 = H, protecting group; R 5 = R 1 , OR 7 ; R 6 = R 2 , protecting group; R 7 = protecting group; at least one of M 4,6,7 =protecting group), (c) reducing the corresponding nitropropanol, (d) alkylating or benzylating the primary amine or (e) reducing the corresponding amide, optionally followed by resolution and/or salt formation. The above compounds are sympathicomimetics and increase blood pressure; they may be administered in the form of pharmaceutical preparations containing them in association with a carrier.</p> |
