| 摘要 |
1474364 Bis-pyrolidinyl tricyclic compounds BRISTOL-MYERS CO 28 Jan 1976 03360/76 Heading C2C Novel compounds of Formula I wherein X is a sulphur or oxygen atom, or a divalent methylene radical of the formula -C(Z 1 Z 2 )- wherein Z 1 and Z 2 are each independently a hydrogen atom or a straight chain lower alkyl group containing from 1 to 4 carbon atoms inclusive; Y is a hydrogen or halogen atom, a trifluoromethyl group, a lower alkyl group containing from 1 to 4 carbon atoms or a lower alkoxy group containing from 1 to 4 carbon atoms and R is a hydrogen atom or a straight chain lower alkyl group containing from 1 to 4 carbon atoms inclusive; or a pharmaceutically acceptable acid addition salt thereof are prepared by reacting a compound of Formula II with a compound of Formula III and POCl 3 or with 2-chlorro-1-(1-pyrolin-2-yl)- 2-pyrroline hydrochloride and optionally converting the product to a salt. Pharmaceutical compositions in conventional forms for oral and parenteral administration and having smooth relaxant, platelet aggregation inhibiting and diuretic activity comprise an above novel compound and a carrier or diluent. |
