| 摘要 |
<p>1380904 Peptides ROHM & HAAS CO 16 Nov 1971 [19 Nov 1970 (2)] 53105/71 Heading C2C [Also in Divisions G1 and A5] Compounds (I): (where R is H; Ph optionally substituted by halogen, 1-4 C-alkyl, OH, 1-4 C-alkoxy, 1-4 C-alkanoyloxy, or 1-4 C-alkoxycarbonyl; 1- 12 C alkyl, optionally substituted by halogen, 1-4 C-alkoxy, OH, 1-4 C-alkanoyloxy, polyoxyalkyl or Ph; 1-12 C-alkoxy; aryloxy of up to 10 C; or divalent alkylene of up to 6 C; NHR<SP>1</SP>CO is amino acid link derived from L- phenylalanine, L-tyrosine, L-leucine, L-methionine, L-tryptophane, L-arginine or L-lysine; Z is a group (II): wherein R<SP>11</SP> is OH, 1-4 C-alkoxy, (1-4 C- alkoxy)-alkoxy, (1-8 C-dialkylamino) alkoxy, NH 2 , 1-4 C-alkylamino, 1-4 C-dialkylamino, -NHCH 2 COR<SP>11</SP> or a salt thereof when R<SP>11</SP> is -OH; Y is -CO- or -SO 2 -; X is OH, 1-4 C-alkyl, halogen, 1-4 C-alkoxy and n<SP>1</SP> is 0, 1 or 2; A and B are residues of amino acids, glycyl, alanyl or glycylglycyl and m and n are 0, 1 or 2) are prepared by methods known per se for preparing peptides by reaction between two amino acid residues. N - Benzoyl - L - phenylalanyl - glycine benzyl ester and the free acid, t-butyloxycarbonylglycyl paminohippuric acid methyl ester, N-glycyl-paminohippuric acid methyl ester, ethyl carbobenzoxyglycyl - p - aminobenzoate, ethylglycyl - paminobenzoate, adipoyl - bis - (phenylalanine) and N-benzoyl-L-tyrosine were prepared as intermediates. Pharmaceutical compositions in forms suitable for oral administration comprise (I) and a diluent, carrier, adjuvant, feedstuff diet supplement or other diagnostically or pharmaceutically active material. Compounds (I) are used as diagnostic agents for the determination of the activity of pancreatic enzymes in an animal organism.</p> |
