| 摘要 |
1396465 1 - Arylideneamino - 4 - (2 - oxo - 3- phenyl - 3 - benzofuryl) - piperazines G D SEARLE & CO 20 Aug 1973 [21 Aug 1972] 39185/73 Heading C2C Novel compounds I in which R is phenyl, 3,4-methylenedioxyphenyl, pyridyl or methylpyridyl and their acidaddition salts are prepared by (1) reacting 1- amino - 4 - (2 - oxo - 3 - phenyl - 3 - benzofuryl)- piperazine with an aldehyde R-CH=O or derivative thereof (preferably acetals, dialkanoates or imino or hydrazo derivatives of the carboxyl group) or (2) reacting a 3-(bromo or chloro)- 3-phenyl-2-benzofuranone with a piperazine III 1 - Amino - 4 - (2 - oxo - 3 - phenyl - 3 - benzofuryl)-piperazine is prepared by condensing 3- bromo-3-phenyl-2-benzofuranone with N-nitroso-piperazine and subsequently reducing the nitroso group. Compounds I are anti-convulsants, and also possess bradykinine-antagonistic, PGE 2 -antagonistic and CNS activities. They form with a carrier a pharmaceutical composition which may be administered orally or parenterally. |
