摘要 |
New piperidinyl-alkyl-benzamides and salts thereof are disclosed, together with a method for the production of the benzamides and salts. The benzamides, which have beta-adrenergic agonist effects, have the general formula <IMAGE> Formula I The hydrochlorides which exemplify the salts, have the general formula <IMAGE> In the foregoing formulas R is hydrogen, an alkyl group having from 1 to 4 carbon atoms, an alkoxy group having from 1 to 4 carbon atoms, halo, amino, hydroxy or trifluoromethyl, n is 1, 2 or 3 when R is methoxy but is otherwise 1, and x is 1, 2 or 3. The hydrochloride salts of the benzamides according to the invention can be produced by the reactions illustrated below: <IMAGE> <IMAGE> +tr <IMAGE> Wherein R, n and x have the meanings set forth above and Y can be -Cl, -F, or -OCH3.
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