| 摘要 |
<p>4-Androstene-3,17-dione and 1,4-androstadiene-3,17-dione are converted to 3-(17 beta -hydroxy-4-androsten-3-on-17 alpha -yl)-propionic acid lactone in three steps by reaction with propargyl alcohol in the presence of an alkali alcoholate of a tertiary alcohol, hydrogenating the thus-produced 17 alpha -(3-hydroxy-propinyl)-17- beta -hydroxy compound with hydrogen in the presence of a complex metallic catalyst to produce 17 alpha -(3-hydroxypropyl)-17 beta -hydroxy-3-keto-androst-4-ene, which is oxidized with chromic acid to the desired lactone.</p> |
