| 摘要 |
Novel 1-substituted-4-benzylpiperidines having alpha -substituents on the 4-benzyl moiety useful as anti-inflammatory agents, sedatives, and tranquilizers are represented by the formula <IMAGE> wherein R represents acetyl, aryloxyloweralkyl, aroylloweralkylcarbamoyl, N-lower-alkylcarbamoyl, N,N-dilower-alkylcarbamoyl, N-arylcarbamoyl, N-( omega -nitrogen containing heterocycle)lower-alkylcarbamoyl, N(- omega -aminolower-alkyl)carbamoyl, 2-hydroxy-3-(o-methoxyphenoxy)propyloxycarbonyl, 2-carbamoylethyl, or 4-(p-fluorobenzoyl)piperidinoethyl; R1 represents hydrogen or hydroxy; R2 represents phenyl, p-fluorophenyl, m-trifluoromethylphenyl or cyclohexyl; Y represents hydrogen or fluorine with the proviso that when Y is hydrogen and R2 is phenyl, R is other than aroylloweralkyl. The pharmaceutically acceptable acid addition salts of the basic compounds of Formula I are included as part of the invention.
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