发明名称 |
15-Deoxy-PGE{HD 1 {B and method for preparing same |
摘要 |
Racemic 15-deoxy, 11,15-deoxy and other prostaglandins and methods for preparing the same. The initial reactant is lithium cyclopentadiene which is reacted with ethyl-7-bromoheptanoate to give the alkylated diene which in turn is oxygenated to a mixture of hydroxycyclopentenones. 2-(6'-carboethoxyhexyl)-4-hydroxy-cyclopenten-1-one is chromatographically recovered from the mixture and reacted with dihydropyran to give the tetrahydropyranyl ether which is then reacted with 1-lithium-1-trans-octene in the presence of tri-n-butylphosphine-copper iodide to produce racemic 15-deoxy-prostaglandin E1 ethyl ester which is chromatographically recovered. The ester is converted to the corresponding prostaglandin by the action of an esterase-producing microorganism.
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申请公布号 |
US4031129(A) |
申请公布日期 |
1977.06.21 |
申请号 |
US19720221058 |
申请日期 |
1972.01.26 |
申请人 |
WISCONSIN ALUMNI RESEARCH FOUNDATION |
发明人 |
SIH, CHARLES J. |
分类号 |
C07C405/00;C07D303/32;C07D309/12;C07F1/02;C07F1/08;C07F5/06;(IPC1-7):C07C177/00 |
主分类号 |
C07C405/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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