Process for preparing 3-acycloxymethyl-2-cephem compounds

摘要

A 3-exomethylenecepham sulfoxide ester is reacted with a mixture of an acyl chloride of the formula <IMAGE> AND THE CORRESPONDING ANHYDRIDE OF SAID ACYL CHLORIDE AT A TEMPERATURE OF FROM ABOUT 70 DEG TO ABOUT 130 DEG C. to produce the corresponding 3-acyloxymethyl- DELTA 2-cephem. This product is useful as an intermediate in the preparation of antibiotically active cephalosporins.