| 摘要 |
<p>As new compounds are provided 9,3'',4''-trialkanoyl SF-837 M1 substances which have therapeutically useful antibacterial activity and do not show any objectionable long-lasting bitter taste upon its oral administration. These 9,3'',4''-trialkanoyl SF-837 M1 substances may be prepared from SF-837 substance, 9,2',3''-tri-acetyl SF-837 M1 substance, 9,2'-di-acetyl SF-837 substance, 9-propionyl SF-837 substance or 9,2'-dipropionyl SF-837 substance by acylating the latter with an alkanoic acid anhydride at 50 DEG -120 DEG C to produce the corresponding 9,2',3'',4''-tetra-alkanoyl SF-837 M1 substance and occasionally the 9,18,2',3'',4''-penta-alkanoyl SF-837 M1 substance, with involving the shift of the 4''-alkanoyl group to the 3''-hydroxyl group. Partial and selective hydrolysis of the 9,2',3'',4''-tetra-alkanoyl SF-837 M1substance and/or the 9,18,2',3'',4''-penta-alkanoyl SF-837 M1 substance so produced gives the desired 9,3'',4''-tri-alkanoyl SF-837 M1 substance.</p> |
