PROCEDIMIENTO PARA LA PREPARACION DE NUEVOS ACIDOS 3-(4-BI- FENILIL)-BUTIRICOS, SUS ESTERES O AMIDAS.

摘要

1445283 Diphenyl derivatives DR KARL THOMAE GmbH 15 Aug 1974 [16 Aug 1973] 36013/74 Headings C2C and C2P The invention comprises compounds of the general Formula I wherein R 1 represents a chlorine or fluorine atom and B represents a hydroxyl group, an alkoxy or aralkoxy group or an amino group and basic salts of those compounds of Formula I wherein B represents a hydroxyl group. The compounds of Formula I are used as pharmaceuticals. Many methods for the preparation of compounds of Formula I are described. Examples 16(a) and 17(a) describe respectively the preparation of 2 - (2 - fluoro [and 2 - chloro] - 4 - biphenyl) - 1 - ethoxycarbonyl - 1 - propylidene triphenyl - phosphorane by refluxing in absolute ethyl acetate ethoxycarbonyl-methylidene triphenyl phosphorane with bromo - 1- (2 - fluoro - 4 - biphenylyl)ethane and 1 - (2- chloro - 4 - biphenylyl) - 1 - bromo - ethane respectively.