| 摘要 |
2065414 9104055 PCTABS00003 Autoimmune diseases are associated with particular immunoglobulin isotypes, particularly the isotypes IgG or IgM, and can be treated by specifically suppressing the production of that immunoglobulin isotype or subtype. Isotypic-specific suppression can be achieved by administering peptides which have an amino acid sequence corresponding to the extracellular segment of the membrane-bound domain (the "migis" segment) of an immunoglobulin of the isotypic class or subclass or an epitope thereof. Suppression can also be achieved by administering antibodies and related and derivative products specific for the migis segment.
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