发明名称 |
1,4-Dithiin (and oxathiin)-yl cephalosporin derivatives, and compositions containing them |
摘要 |
New cephalosporin compounds of the formula: <IMAGE> (I) in which A is oxygen or sulphur, R1 is hydrogen or acetoxy and R2 is carboxy or a radical of the formula: <IMAGE> (II) in which the radical <IMAGE> (III) is a radical which can be easily removed enzymatically, and in which R3 is hydrogen or straight or branched chain C1-4 alkyl and R4 is straight or branched chain C1-4, alkyl or cyclohexyl, together with its diastereoisomeric forms and mixtures thereof, its acid addition salts and, where appropriate, its pharmaceutically acceptable non-toxic metal salts and addition salts with nitrogen-containing bases other than ammonia, exhibit valuable anti-bacterial properties, in particular against Gram-positive and Gram-negative bacteria.
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申请公布号 |
US4029781(A) |
申请公布日期 |
1977.06.14 |
申请号 |
US19750617066 |
申请日期 |
1975.09.26 |
申请人 |
RHONE-POULENC INDUSTRIES |
发明人 |
BERGER, CHRISTIAN;FARGE, DANIEL;GROS, GEORGES;MESSER, MAYER NAOUM;MOUTONNIER, CLAUDE |
分类号 |
C07D501/22;A61K31/546;C03C17/28;C07D501/06;C07D501/20;C07D501/34;(IPC1-7):C07D501/22;A61K31/54 |
主分类号 |
C07D501/22 |
代理机构 |
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代理人 |
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地址 |
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