2-(THIENYL-3SU-AMINO)-1,3-DIAZA-CYCLOALKENES AND PROCESS FOR P REPARING THEM

摘要

1324646 Nitrofuran derivatives SCHERING AG 13 Aug 1970 [13 Aug 1969] 38997/70 Addition to 1236634 Heading C2C Novel compounds of Formula I in which X is a direct bond or a group of the formula -CH=CY- in which Y is H, C 1-5 alkyl, aryl or aralkyl, and R is an alkyl or alkoxy group containing 1 to 6 carbon atoms which may be interrupted by an oxygen atom and which is substituted by a hydroxyl group esterified with an N-alkyl-carbamic acid containing 2 to 7 carbon atoms or with a semi-ester of carbonic acid containing 2 to 7 carbon atoms or with a sulphonic acid of formula R1-SO 3 H in which R1 is a C 1-6 aliphatic hydrocarbyl, phenyl or tolyl group, are prepared by esterifying the corresponding hydroxyl compounds by reaction with a corresponding alkyl isocyanate, chlorocarbonic acid ester or sulphonyl chloride. Pharmaceutical compositions having antitrichomonal activity, for oral or topical administration, comprise a compound of Formula I together with a pharmaceutical carrier.