发明名称 |
Process of preparing penicillamine |
摘要 |
Improvements in the process of preparing penicillamine or a homolog thereof by reacting an alpha -carbon atom branched aldehyde, sulfur and ammonia to form a thiazoline- DELTA 3, reacting the thiazoline- DELTA 3 with anhydrous hydrogen cyanide to form a thiazolidine-4-carbonitrile, hydrolyzing the nitrile to form a mixture of the salt of the thiazolidine-4-carboxylic acid and ammonium salts, separating off the ammonium salts and hydrolytically decomposing the thiazolidine-4-carboxylic acid, wherein under the action of a mineral acid the thiazolidine-4-carbonitrile is in the first stage converted at low temperatures into the salt of the thiazolidine-4-carbonamide and then at higher temperatures converted into the salt of the thiazolidine-4-carboxylic acid.
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申请公布号 |
US4028406(A) |
申请公布日期 |
1977.06.07 |
申请号 |
US19760657835 |
申请日期 |
1976.02.13 |
申请人 |
DEUTSCHE GOLD- UND SILBER-SCHEIDEANSTALT VORMALS ROESSLER |
发明人 |
ASINGER, FRIEDRICH;OFFERMANNS, HERIBERT;GLUZEK, KARL-HEINZ |
分类号 |
C07D277/06;(IPC1-7):C07C99/00 |
主分类号 |
C07D277/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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