| 摘要 |
<p>(-)-1-Methyl-4-(3-cyano-5H-dibenzo[a,d]cyclohepten-5-ylidene)piperi dine and (+)-1-methyl-4-(3-cyano-5H-dibenzo[a,d]cyclohepten-5-ylidene)piperidin e are prepared in virtually pure form. These compounds are obtained by preparing the diastereomeric salts of the corresponding (+/-)-racemate in suitable solvents using optically active acids. The (-)-form, which is virtually free of the (+)-form, is then removed by crystallisation. The salt obtained is then converted into the free base, and the (+)-form is isolated from the residue as the free base. The (+)-form of the base and also the corresponding acid addition salts can be used as peripheral and central anticholinergics. The (-)-form of the base including corresponding acid addition salts can be used as sedatives.</p> |
