| 摘要 |
An N-[1-Z-4(or 3)-piperidyl]acylanilide, having antidiarrheal utility, is prepared by reacting an N-[4(or 3)-piperidyl]acylanilide with a Z-halide or by reacting a 4(or 3)-(Q-anilino)-1-Z-piperidine with an acyl halide or anhydride, where Z is lower-alkyl, 3-cyano-3,3-diphenylpropyl or 2-cyanoethyl, acyl is propionyl, lactyl, dichloroacetyl or carbethoxy, and Q is hydrogen or (halo)n where halo is fluoro or chloro and n is 1 or 2. Also included are corresponding N-[4(or 3)-pyridyl]-, N-(3-quinuclidinyl)-, and N-(8-Z-3-nortropanyl)-acylanilides.
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