PROCEDIMIENTO PARA LA PRODUCCION DE NUEVOS DERIVADOS DEL DI-N-OXIDO (1,4) DE 3-AMINO-BENZO-1,2,4-TRIACINA.

摘要

1423585 Benzo-1,2,4-triazine-1,4-di-N-oxides BAYER AG 15 Nov 1973 [15 Nov 1972 9 Dec 1972 27 April 1973] 53070/73 Heading C2C Novel benzo-1,2,4-triazine-1,4-di-N-oxides of the general formula wherein each of X1 and X2 is a hydrogen or halogen atom or an optionally substituted alkyl or alkoxy group and A is -R, -COR1, -COCH 2 COCH 3 or -CONHR2, in which R is an optionally substituted alkyl, alkenyl or aralkyl group, R1 is a hydrogen atom or an optionally substituted alkyl or aryl group and R2 is an optionally substituted alkyl, cycloalkyl or aryl group, are prepared (a) when A is -R, by alkylating, alkenylating or aralkylating the corresponding compound in which A is a hydrogen atom with RY, wherein Y is a labile radical which is split off during the reaction; (b) when A is -COR1 or -COCH 2 COCH 3 , by acylating the corresponding compound in which A is a hydrogen atom with ketene, diketene or R1COY; and (c) when A is -CONHR2, by reacting the corresponding compound in which A is a hydrogen atom with R2NCO. The 3 - amino - benzo - 1,2,4 - triazine - 1,4- di-N-oxide starting materials used in (a), (b) and (c) above are prepared by reacting a benzofuroxan of the general formula with disodium cyanamide. Pharmaceutical compositions having antimicrobial and growth-promoting activity comprise, as active ingredient, a benzo-1,2,4-triazine-1,4-di-N-oxide of the first general formula above, together with an appropriate carrier.