| 摘要 |
Compounds are disclosed which may be represented by the formula: wherein Het1 and Het2 may each be imidazole which may be substituted by methyl or bromo, pyridine which may be substituted with hydroxyl, methoxy, chloro or bromo, thiazole or isothiazole; X is sulphur, NH2, NOH, NCN, or CHNO2; B1 and B2 are lower alkylene groups such that either B1 is (CH2)2 or (CH2)3 and B2 is -CH2CHR-, -CHRCH2-, , or wherein R is methyl or ethyl or B1 and B2 are both selected from and . The compounds are useful in blocking histamine H2-receptors and act to inhibit the biological actions of histamines which are not inhibited by "antihistamines". The compounds find use for example, as inhibitors of gastric acid secretion, as anti-inflammatory agents and as agents which act on the cardiovascular system. |
