2-(4-BIPHENYLYL)-TETRAHYDROFURANS AND PROCESSES FOR THEIR PREPARATION

摘要

1412663 Substituted tetrahydrofuran compounds and pharmaceutical compositions containing them DR KARL THOMAE GmbH 16 Aug 1973 [17 Aug 1972] 38840/73 Heading C2C The invention comprises compounds of formula wherein R 1 represents hydrogen or a halogen atom. These compounds may be obtained by cyclohydrating a compound of formula wherein R 1 is the same as defined above. Preferred cyclohydrating agents comprise an acid, acid salt, an anhydrous metal salt, a sulphonic acid halide in the presence of a tertiary organic base, or a cation ion-exchanger containing sulphonic acid groups. The intermediate of Formula II is obtained by the reduction of 4,-(4-biphenylyl)-4-oxo-butyric acid esters with complex hydrides; and the intermediate of Formula III is obtained by the reduction of 4-(4-biphenylyl)-but-3-enic acid with complex hydrides. The invention also comprises an anti-philogistical composition which contains as an active ingredient a compound according to the invention in association with a pharmaceutical carrier or excipient. The composition is suitable for oral, rectal or parenteral administration.