| 摘要 |
1319127 Asymmetric reduction of secosteroids AMERICAN HOME PRODUCTS CORP 9 Sept 1970 [28 April 1970] 43095/70 Heading C2C An optically active d-13#-alkyl-17#-hydroxy- 8,14 - secogona - 1,3,5(10),9(11) - tetraen - 14- one is prepared by asymmetric reduction of a 13 - alkyl - 8,14 - secogona - 1,3,5(10),9(11) - 14, 17-dione with a reducing strain of the microorganism Pichia farinosa or an enzyme produced therefrom, particularly P. farinosa NRRL Y-118 or CBS 185. The following illustrates the process wherein R and R<SP>1</SP> are each alkyl. Reference has been directed by the Comptroller to Specification 1,165,144. |
